Emergency services rushed to the scene and one man was helped from the house with very serious injuries. He was assessed and treated before being rushed on blue lights to Queen Elizabeth Hospital in Birmingham.
Ambulance service staff said his condition was “life-threatening”. Four other men received minor injuries.
A West Midlands Ambulance Service spokesman said: “Four further men have been assessed by ambulance crews for minor conditions but have been discharged at the scene.
“Members of the Hazardous Area Response Team continue to work with specialist firefighters at the scene.”
Huge flames were seen coming out of the remains of the house after the explosion as parts of the home fell into the fire and police urged residents watching on to get back.
The road has been cordoned off by the authorities as investigations continue.
West Midlands Police has also asked people not to post or share images of the explosion.